The Chicago American Indian Community Collaborative (CAICC) was established in 2012 and consists of fifteen Native American organizations and programs that are focused on “improving conditions for Native Americans in the Chicago area.” CAICC was founded to create cohesion across the many organizations that serve the Native community and provide a unified voice in a city where Native perspectives are often ignored and invisible. From its beginning, CAICC has established goals to meet the current and future needs of Native Americans who continue to call Chicago home and to sustain connections to Chicago’s Native past.  Today, CAICC maintains four subcommittees that attend to pressing issues for the Chicago Native community. Among the organization's greatest accomplishments include: hosting an annual Education Conference that brings together leaders in Native education from across the nation; holding two Native American Summits in 2022 and 2024 at the state capitol to call attention to community priorities; and assisting in the passage of two state bills: HB1633, which mandates the teaching of Native history in K-12 classrooms, and SB1446, which ensures that Native students are allowed to wear culturally significant regalia at graduation ceremonies.

The Saint Kateri Center of Chicago, named for Native American Saint Kateri Tekakwitha (Mohawk and Algonquin), traces its beginnings to the Anawim Center in Uptown in 1982. Chicago Native American elders, Peggy Des Jarlait (Arikara), Irene Big Eagle (Odawa), Inez Marie Running Bear Dennison (Rosebud Sioux), and others who practiced Catholicism believed that there was a need for a place for Catholic Native people. They requested support from Dominican nuns to establish a center for Catholic Native people to practice their religion while also learning about Native American religious practices. The Archdiocese of Chicago began to sponsor the center in 1987, and after moving to Saint Benedict's Parish in 2010, the Anawim Center became the Saint Kateri Center.