Founded in 2007 by Dr. Dorene Wiese (White Earth Band Ojibwe), the American Indian Association of Illinois (AIAI) is among the most recently Native founded and driven organizations in Chicago. AIAI provides student centered assistance and services for students in public, private, and tribal schools not only in Chicago but throughout the United States. A few of the programs implemented by AIAI include the Medicine Shield Indian School Program, the Black Hawk Performance Company, and the Native American Language Institute. AIAI's leadership is dedicated to grounding the Native youth of the city today in the longstanding activism within Chicago and individual's ties to their tribal nations.

Its leadership under Dr. Wiese and others also connects the organization to institutions that are no longer active, including the Institute of Native American Development (INAD) at Truman College and Native American Educational Services (NAES) College. This connection has grounded IAIA in the goals of many Native driven organizations in Chicago, to provide space for Native students to receive support and make their mark within the rich history of the Native community within the city.

The Chicago American Indian Center was created in 1953, at a time of great change for the Chicago Native community. Native peoples had been moving to and from Chicago since forced removal in the 1830s, but the Bureau of Indian Affairs's voluntary relocation program (1952-1972) meant that there was a significant increase in Chicago's Native population. In response to this change, a group of organizations including the Bureau of Indian Affairs (BIA), the Chicago Citizens’ Advisory Board, the American Indian Club, the Indian Council Fire, and the American Friends Service Committee began meeting in July of 1953 with the intention of creating connections between Native Americans moving to the city and the city itself. These meetings and the work of Native people already in the city led to the creation of the All-Tribes American Indian Center, which opened its doors in a rented space on LaSalle Drive in late 1953.

At the LaSalle location the American Indian Center began hosting annual powwows and formed clubs to facilitate community building in a growing intertribal Chicago Native community. The Canoe Club, the Photography Club, an all Native Boy Scout troop, a day camp, educational services, and job assistance were a few of the many clubs or programs developed in the first decade of the Center. Leaders within the American Indian Center and the Chicago Native community including Ben Bearskin, Frank Fastwolf, Tom Greenwood, Dorothy Holstein, Robinson Johnson, Willard LaMere, and many others participated in the planning for the famed Chicago American Indian Conference in July 1961 at the University of Chicago. The conference drew Native activists from across country to Chicago and resulted in drafting The Declaration of Indian Purpose, a document outlining the needs and priorities of Native communities that was delivered to President Kennedy.

In 1963, the center moved to North Broadway for several years, before moving to Uptown on West Wilson Avenue in 1967. Here the Center continued to host annual powwows, hold gatherings, develop programs, and participate in activism that asserted the presence of Native peoples in the city. In 2017, the American Indian Center moved out of Uptown and into its current location in Albany Park.

Over the past seventy years, the Center, its leadership, and the Chicago Native community have worked to uphold the legacy of the institution to serve the community and sustain the Center’s mission. It remains one of the oldest American Indian centers in the country.

The American Indian Health Services of Chicago (AIHS), began as a non-profit in 1974 and has continued to be a pillar of the Chicago Native community. It is “dedicated to providing quality culturally competent healthcare to the American Indian and Alaska Native community and other underserved populations.” AIHS offers services including gatherings focusing on mental health, its Senior Socials, counseling services, and general community outreach. These range from their Diabetes Talking Circle, Wellbriety Meetings, a storytelling series, Men’s Talking Circle, and their powwows. 

AIHS’s existence and a continued need for their services within the community also show a larger issue that impacts Native American communities: access to quality and knowledgeable healthcare. For Native people who participated in the Bureau of Indian Affairs's voluntary relocation program in the mid-twentieth century and struggled to find consistent work or support from the BIA, affordable healthcare or health insurance was difficult to find without community support. The lack of culturally competent care outside of AIHS and community based efforts had been and continues to be a struggle for Native peoples, especially Native women in cities.  

The founding of AIHS followed the same mission as earlier organizations, to provide whatever the Chicago Native community needed. After fifty years of serving the community, AIHS continues to adapt to and serve all Natives of Chicago. 

The California Indian Manpower Consortium, Inc. (CIMC) was founded in 1978 to promote the social welfare, economic development, and educational needs of Native communities in California. Although the nonprofit is based in California, it has created a consortium of tribal nations, tribal communities, and organizations across the United States. As the only field office outside of California, the Chicago office is able to cater to the needs of the Chicago community. CIMC provides job training, educational training, job search or placement, leadership programs, and counseling or career planning.

The Caroline and Ora Smith Foundation, housed in Chicago, supports opportunities for Native American girls and women in grade school to graduate programs in Science, Technology, Engineering, and Math (STEM). Founded by Mary Smith (Cherokee) and named after her mother and grandmother, the organization's overall mission is to facilitate a larger number of Native American women in STEM fields. Although it is based in Chicago and working with its first cohort in Chicago and Milwaukee, the Foundation is working to offer community and culturally specific programming to Native women across the United States.

The Chicago Public Schools (CPS) American Indian Education Program provides support for Native American students and their families within the CPS district. Services it provides include after-school tutoring, cultural programming, workshops for students and parents, and programming geared toward students finishing their education within the CPS system or continuing to college. The program is overseen by the Citywide American Indian Education Council (CAIEC), and they monitor the program while also serving as intermediaries between the Native American community and CPS.

The Newberry Library is a cultural institution whose collections and exhibitions offer a portal to more than six centuries of human history. Among its many collections, the Newberry is home to the Edward E. Ayer American Indian and Indigenous Studies Collection, which includes thousands of print and manuscript materials related to American Indian and Indigenous people. The collection includes content on Indigenous people in North and South America from pole to pole, coast to coast, and beyond into the Pacific.

In 1972, Métis author and activist D'Arcy McNickle helped found the Center for the History of the American Indian at the library, which aimed to promote the research of Native American history, increase access to the collection for Native communities, and revise the ways Native peoples had been misrepresented in these histories. The center was later renamed the D'Arcy McNickle Center for American Indian and Indigenous Studies, and has provided training to graduate students and presented public programming and project, often in collaboration with the Chicago Native community. Several of its current projects aim toward expanding the accessibility of its collections to tribal communities and collaborating with the Native communities to align with Native perspectives, knowledge systems, and cultural practices.

Merge this text with the above: Initially founded in 1972 as the Center for the History of the American Indian, the D’Arcy McMickle Center was established to promote the research of Native American history and revise the ways Native peoples have been misrepresented in these histories. Located within the Newberry Library in Chicago it is named after Salish Kootenai activist, writer, and its first director D’Arcy McNickle. Since its founding the Center has provided training in American Indian and Indigenous Studies to students and presented public programming for the Chicago Native community. Several of its current projects aim toward expanding the accessibility of its collections to tribal communities and collaborating with the Native communities to align with Native perspectives, knowledge systems, and cultural practices.

While it initially began meeting within the American Indian Center as a club, the Menominee Social Club of Chicago developed as Menominee individuals and families needed support after moving to the city on their own or through the twentieth century voluntary relocation program by the Bureau of Indian Affairs (BIA). In 1994, the Menominee community in Chicago reached out to the tribal government to ask for support, and in 1996 the Menominee Nation Tribal Council recognized the Menominee Community Center of Chicago as a distinct but important part of the Menominee Nation. After this recognition, the Community Center was designated as a non-profit tribal program. The efforts by both those on the reservation and the urban Menominee community members in the creation of the center demonstrates the continued connections between Menominee peoples and the lands and family they have on the Menominee Reservation in Wisconsin.

The Mitchell Museum of the American Indian in Chicago was founded in 1977 after John and Betty Seabury Mitchell donated their collection of Native American artifacts to Kendall College before the museum became its own institution in 2006. It's original name was the Green Bay Trading Co. This collection contained objects from tribal nations across North America, leading the initial mission of the museum to focus on the history and diversity of all tribes to match the expansive the collection.

After consulting with Native community members in Chicago and throughout the Great Lakes, the museum adjusted this mission to focus more on the histories of Chicago’s Native community and Tribal Nations in the Great Lakes Region of the United States and Canada. The Mitchell Museum continues to work alongside other organizations to highlight Native representation in literature, music, and art in its exhibits and projects.

The Native American Chamber of Commerce of Illinois (NACC-IL) is an organization within Illinois that aims to provide business education, mentoring, and networking opportunities for Native American businesses. It seeks to highlight how vital it is to have businesses created and owned by Native people for community cultural and economic growth. It is one of fourteen Chambers of Commerce around the country that support business education and support for Native Americans. 

The Center for Native American and Indigenous Research (CNAIR) at Northwestern University was founded in 2014 as a larger movement of initiatives within Northwestern University that has worked to strengthen the relationship between Northwestern and Native American communities. These initiatives include the John Evans Study Committee, the Native American Outreach and Inclusion Task Force, the Native American Leadership Council, and student participation in projects for the Chicago Native community.

The Saint Kateri Center of Chicago, named for Native American Saint Kateri Tekakwitha (Mohawk and Algonquin), traces its beginnings to the Anawim Center in Uptown in 1982. Chicago Native American elders, Peggy Des Jarlait (Arikara), Irene Big Eagle (Odawa), Inez Marie Running Bear Dennison (Rosebud Sioux), and others who practiced Catholicism believed that there was a need for a place for Catholic Native people. They requested support from Dominican nuns to establish a center for Catholic Native people to practice their religion while also learning about Native American religious practices. The Archdiocese of Chicago began to sponsor the center in 1987, and after moving to Saint Benedict's Parish in 2010, the Anawim Center became the Saint Kateri Center. 

Established in Schaumburg, Illinois in 2005, the Trickster Cultural Center features contemporary Native American art and works to provide space for Native artists to show their work along with educating people on the impact of Native American art. Named for the trickster archetype in Native American traditions that teaches life lessons and other truths, the Trickster Cultural Center positions itself in this legacy of the trickster by creating an environment to educate others about the present-day Native communities. Alongside other Native driven and founded institutions in and around Chicago, the Trickster Cultural Center supports community efforts to provide culturally focused education for Native youth through summer and cultural camps.

The organization has also led the National Gathering of American Indian Veterans in Wheaton, Illinois since 2015, and this has led to a shift in its original mission statement to now promote the legacy of Native veterans alongside contemporary Native art.

The Tunica-Biloxi Chicago Branch Office is a satellite office for the Tunica- Biloxi Nation of Louisiana. In Chicago, it serves as a gathering place for both Tunica-Biloxi tribal members, as well as the broader Native community in Chicago. The office hosts both educational and cultural gatherings about a variety of subjects, including beading, language, and cooking. Members of the Tunica-Biloxi Nation have been living in Chicago for more than 100 years, even though their an ancestral lands, reservation, and governmental operations are located in Marksville, Louisiana. Tribal members in Chicago began trying to establish a satellite office in Chicago in the 1990s, but it was not until 2019 that the branch office was officially opened.